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胡绪红教授和罗德平教授合作在Chin. Chem. Lett.发表研究论文
 添加时间:2020/11/30 发布:

Access to multi-functionalized oxazolines via silver-catalyzed heteroannulation of enamides with sulfoxonium ylides

Rui-Hua Liua,#, Qi-Chao Shana,#, Ya Gaoa, Teck-Peng Loha,b,*, Xu-Hong Hua,*

a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China

b Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore

# These authors contributed equally to this work.

Abstract: Disclosed herein is an efficient Ag-catalyzed [4+1] heteroannulation reaction of enamides with α-carbonyl sulfoxonium ylides. The diastereoselective transformation provides a practical access to a diverse range of multi-functionalized oxazoline derivatives. The synthetic utility of the resultant tetra-substituted oxazolines is further demonstrated by a series of useful manipulations into valuable building blocks of pharmaceutical relevance.

Chin. Chem. Lett. https://doi.org/10.1016/j.cclet.2020.10.007 (2019年影响因子4.632)

论文链接https://www.sciencedirect.com/science/article/pii/S1001841720305908?via%3Dihub






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