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胡绪红教授课题组在Organic Letters发表研究论文
 添加时间:2020/11/30 发布:

Selective Dehydrogenative Acylation of Enamides with Aldehydes Leading to Valuable β‑Ketoenamides

Rui-Hua Liua, Zhen-Yao Shena, Cong Wanga, Teck-Peng Loha,b, and Xu-Hong Hua,*

a Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing 211816, China

b Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore

Abstract: We have presented a unique example of dehydrogenative acylation of enamides with aldehydes enabled by an earthabundant iron catalyst. The protocol provides the straightforward access to valuable β-ketoenamides with ample substrate scope and excellent functional group tolerance. Notably, distinct C−H acylation of enamide rather than at N−H moiety site occurs with absolute Z-selectivity was observed. Late-stage modifications of complex molecules and versatile synthetic utility of β-ketoenamides further highlight the practicability of this transformation.

Org. Lett. 2020, 22, 944-949. (2019年影响因子6.091)

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